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Zonal organization: Articular cartilage has superficial zone (tangential collagen orientation, highest cell density), middle zone (random collagen orientation, largest proteoglycans), deep zone (perpendicular collagen orientation, calcified interface with bone), and tidemark (boundary between calcified and uncalcified cartilage)

Thereby, the noted healing of these fistulas may have additional general significance

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Only a healthcare professional should administer the injection

The temperature difference between refrigerated solution and body tissue creates a localized reaction that manifests as stinging or burning